The Biochemical Basis of Aging
DOI:
https://doi.org/10.62802/x30c3217Keywords:
aging, oxidative stress, telomere shortening, mitochondrial dysfunction, proteostasis, senescence, epigenetics, longevity, healthspan, anti-aging therapiesAbstract
Aging is a complex biological process driven by intricate biochemical mechanisms that affect cellular function, tissue integrity, and systemic homeostasis. Central to the biochemical basis of aging are phenomena such as oxidative stress, telomere shortening, epigenetic alterations, and the accumulation of damaged macromolecules. These processes lead to gradual functional decline and increased susceptibility to age-related diseases. Emerging research highlights the pivotal roles of mitochondrial dysfunction, proteostasis imbalance, and chronic inflammation in accelerating the aging process. Furthermore, interventions targeting these pathways—such as caloric restriction, senolytic therapies, and the use of pharmacological agents like rapamycin—offer promising avenues for modulating aging and extending healthspan. This paper explores the molecular pathways underlying aging, their implications for health and longevity, and potential therapeutic strategies. By uncovering the biochemical mechanisms that govern aging, this study aims to contribute to the development of interventions that promote healthier aging.
References
Anderson, B. (2024). Bioelectricity: A top-down control model to promote more effective aging interventions. Bioelectricity, 6(1), 2-12.
Asejeje, F. O., & Ogunro, O. B. Deciphering the mechanisms, biochemistry, physiology, and social habits in the process of aging.
Bondy, S. C. (2024). Mitochondrial Dysfunction as the Major Basis of Brain Aging. Biomolecules, 14(4), 402.
Chen, P. X., Zhang, L., Chen, D., & Tian, Y. (2024, February). Mitochondrial stress and aging: Lessons from C. elegans. In Seminars in Cell & Developmental Biology (Vol. 154, pp. 69-76). Academic Press.
Dominguez, L. J., Veronese, N., & Barbagallo, M. (2024). Magnesium and the Hallmarks of Aging. Nutrients, 16(4), 496.
Fuso, A. (2024). Aging and Disease: the epigenetic bridge. In Epigenetics in Human Disease (pp. 1177-1218). Academic Press.
Gorgzadeh, A., Amiri, P. A., Yasamineh, S., Naser, B. K., & Abdulallah, K. A. (2024). The potential use of nanozyme in aging and age‐related diseases. Biogerontology, 1-31.
Mendoza-Núñez, V. M., & Mendoza-Soto, A. B. (2024). Is Aging a Disease? A Critical Review Within the Framework of Ageism. Cureus, 16(2).
Niu, B., Wu, J. X., Huang, X. L., Lei, S. F., & Deng, F. Y. (2024). Telomere length is a driving hallmark for aging-related biochemical hallmarks: evidence from the shared genetic effect and causal inference. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 79(4), glad275.
Xiong, J., Wang, F., Yang, Y., Yang, Y., & Liu, Z. (2024). Preventive effect of human umbilical cord mesenchymal stem cells on skin aging in rats. Heliyon, 10(2).
Published
Issue
Section
