The Role of Epigenetic Modifications in Cellular Differentiation and the Development of Complex Diseases

Rea Barlas

doi:10.62802/d001wt61

Authors

Rea Barlas Author https://orcid.org/0000-0001-8599-761X

DOI:

https://doi.org/10.62802/d001wt61

Keywords:

Epigenetics, Cellular Differentiation, DNA Methylation, Histone Modification, Chromatin Remodeling, Disease Pathogenesis, Biomarkers, Personalized Medicine

Abstract

Epigenetic modifications play a pivotal role in cellular differentiation and the onset of complex diseases by regulating gene expression without altering the underlying DNA sequence. Mechanisms such as DNA methylation, histone modification, and chromatin remodeling orchestrate the transition from pluripotent stem cells to specialized cell types, ensuring tissue-specific functionality. This research delves into the intricate interplay between these epigenetic regulators and their involvement in developmental processes. Moreover, it examines how aberrations in epigenetic landscapes contribute to the pathogenesis of diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. By employing advanced techniques like single-cell epigenomics and CRISPR-based epigenetic editing, this study aims to uncover novel biomarkers and therapeutic targets. The findings highlight the dynamic and reversible nature of epigenetic marks, offering promising avenues for personalized medicine. Understanding the role of epigenetic modifications in cellular differentiation and disease development is essential for advancing diagnostics, therapeutics, and our broader understanding of human biology.

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